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Advances in Research and Applications by Paul L. Munson, John Glover, Egon Diczfalusy and Robert E.

By Paul L. Munson, John Glover, Egon Diczfalusy and Robert E. Olson (Eds.)

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VII. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . 111 . . . 112 References . . . . . . . . . . , . . . . . . . . . . . . I. INTRODUCTION Progress in steroid analysis has been remarkable in the last 15 years. Much of our present knowledge in steroid endocrinology could not have been acquired without the development of radioimmunoassay and other competitive protein-binding methods. These methods have provided the sensitivity and speed required for measurement of physiological concentrations of steroid hormones in large series of samples (see Gray and James, 1979).

Hammarstrom, S. (1981a). Conversion of 5,8,11-eicosatrienoic acid to leukotrienes C3 and Ds. J. Biol. Chem. 256, 2275-2279. LEUKOTRIENES 29 Hammarstrom, S. (1981b). Conversion of ‘*C-labeled eicosapentaenoic acid (n-3) to leukotriene C,. Riochim. Riophys. Acta 663, 575-577. Hammarstrom, S. (1981~). Metabolism of leukotriene C3 in the guinea pig. Identification of metabolites formed by lung, liver and kidney. J . Riol. Chem. 256, 9573-9578. Hammarstrom, S . Adu. Prostaglandin, Thromboxane Leukotriene Res.

1979). Structure of leukotriene C: Identification of the amino acid part. Riochem. Riophys. Res. Commun. 91, 1266- 1272. , Clark, D. , and Corey, E. J . (1980). Stereochemistry of leukotriene C-1. Biochem. Riophys. Res. Commun. 92,946-953. , and Rbdmark, 0. (1980). Leukotriene C,: Isolation from human polymorphonuclear leukocytes. FERS Lett. 122, 87- 90. , and Mathe, A. (1977). Lung function and the role of prostaglandins. Zn “Asthma Physiology, Immunopharmacology and Treatment” (L. M. Lichtenstein and K.

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