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Aging: The Paradox Of Life: The biological reasons for aging by Robin Holliday (auth.)

By Robin Holliday (auth.)

For centuries humans were questioned via the inevitability of human getting older. for many of the second one 1/2 the 20th century getting older remained a secret, or an unsolved organic challenge. on the finish of the 20 th century a extraordinary medical discovery emerged. It was once now not a unmarried discovery within the traditional experience, since it used to be in line with a chain of vital interconnected insights over relatively a protracted time period. those insights made it attainable for the first actual time to appreciate the organic purposes for getting older in animals and guy. it will possibly already be stated, even though, that the various observations and insights that designate getting older aren't authorized as proven wisdom for a very long time. the sector remains to be filled with scientists, and non-scientists, who're simply chuffed to move on speculating in regards to the "mystery" of getting older. the purpose of this ebook is to dispel lack of expertise through explaining in non-technical language what are the explanations for getting older and the parable of over the top prolongation of life.

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The resources saved by B are channelled into reproduction instead. This means that B has more reproductive success than A, and natural selection will favour its survival. The same argument arises from the fundamental reasoning of Malthus and Darwin. Malthus realised that the full reproductive potential of a species such as man can never be realised. Such reproduction, if many offspring survive and also reproduce, is logarithmic or exponential. To put this in simple numbers, suppose each family consisted of four children, each of which also had four children, and so on.

What are the globin genes doing in the brain? They are there, but not expressed, whereas specialised brain cell proteins are expressed, but not in blood cells. These epigenetic controls, and their stability, is now a very active field of research. It is well known that mutations in certain genes are liable to trigger cancer, and also that the incorrect turning on and off of particular control mechanisms, other than by mutations, is also important. It turns out that the stability of cells is greater in long lived mammals such as Maintenance of the Body 23 man, than in short lived mammals such as mice.

A large part of biological research is devoted to a better understanding of maintenance mechanisms, but few of these scientists realise that their work, in one way or another, also relates to the study of ageing. It is also apparent that a very large number of genes are necessary for all maintenance functions, so these genes also have a role in determining longevity and lifespan. This is quite contrary to the view, put about by some who study ageing, that there are just a few “gerontogenes” which determine our lifespan, or that of animals.

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