By Erik De Clercq
Through targeting common molecular mechanisms of antiviral medications instead of cures for person viruses, this prepared reference offers the severe wisdom had to enhance completely novel therapeutics and to focus on new viruses.
It starts with a basic dialogue of antiviral concepts, through a huge survey of recognized viral goals, similar to opposite transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, in addition to their identified inhibitors. the ultimate part comprises numerous instances reports of contemporary winning antiviral drug development.
Edited via Erik de Clercq, the area authority on small molecule antiviral medications, who has constructed extra new antivirals than somebody else.
Read or Download Antiviral Drug Strategies, Volume 50 (Methods and Principles in Medicinal Chemistry) PDF
Best medical ebooks books
Fort Connolly’s America’s best medical professionals® for melanoma represents the much-needed and long-overdue solution for shoppers – and physicians - looking the pinnacle melanoma experts. citadel Connolly’s physician-led examine crew has tackled a number of the difficult matters and built standards for choice. citadel Connolly’s good revered nationwide survey method that has enabled them to spot the top physicians in additional than twenty scientific specialties linked to the prevention, analysis and remedy of cancers.
With a rise of the inhabitants of aged humans in sleek society because of advances in drugs and healthcare amenities, there's additionally a rise within the occurrence and length of continual health problems. equally, complex age is taken into account an important determinant of melancholy and terrible caliber of existence.
CS is an unbranched, polydisperse, complicated glycosaminoglycan extracted and purified from quite a few tissues. This polyanion is interacting with either plasma and cells, it could modulate many biochemical and physiologic tactics. as a result of the presence of sulfate teams in numerous quantities and found in numerous positions, CS represents a truly heterogeneous kinfolk of polysaccharides.
Extra resources for Antiviral Drug Strategies, Volume 50 (Methods and Principles in Medicinal Chemistry)
1987) Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral Research, 8, 261–272. , and Balzarini, J. (2002) 6-[2(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. Journal of Medicinal Chemistry, 45, 1918–1929. , and Snoeck, R. (2007) Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry, 50, 1069–1077. , and j25 j 1 Outlook of the Antiviral Drug Era 26 83 84 85 86 87 88 89 90 Snoeck, R.
And Neyts, J. (2008) Comparative in vitro 100 101 102 103 104 105 anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. Antimicrobial Agents and Chemotherapy, 52, 3433–3437. , and Neyts, J. (2006) A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase. Journal of Virology, 80, 149–160. , and Neyts, J. (2009) Substituted imidazopyridines as potent inhibitors of HCV replication. Journal of Hepatology, 50, 999–1009.
And Picker, D. (1992) Potent and selective inhibition of human immunodeﬁciency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event. Proceedings of the National Academy of Sciences of the United States of America, 89, 5286–5290. , and Matthews, T. (1993) A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virusmediated cell–cell fusion. AIDS Research and Human Retroviruses, 9, 1051–1052. R. (1993) Rational design of potent sialidase-based inhibitors of inﬂuenza virus replication.