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Cardiac Glycosides: Part I: Experimental Pharmacology by Kurt Greeff

By Kurt Greeff

Following the monographs by way of STRAUB (1924) and LENDLE (1935), this is often the 3rd contribution to the "Pharmacology of Cardiac Glycosides" in the guide of Experimental Pharmacology, which was once based through ARTHUR HEFFTER and con­ tinued by means of WOLFGANG HEUBNER. due to the want created through the size of time that had elapsed on account that LENDLE'S paintings, the editorial board asked the swift ap­ pearance of this 56th quantity, which represents present wisdom of the pharma­ cology and scientific pharmacology of cardiac glycosides. that allows you to steer clear of any hold up, quite a few authors have been invited to give a contribution simply because shorter contributions take much less time to organize and are accordingly extra updated. the drawback is that a few overlap among sure chapters couldn't be shunned, regardless of the editor's efforts. Overlapping can, besides the fact that, really be worthwhile, in that differing evaluations will be supplied and topical concerns mentioned from various viewpoints. This re­ minds the reader that medical horizons in drugs should still frequently be widened or revised. i need to thank DR. ALANNA Fox and DR. okay. ANANTHARAMAN for his or her aid and recommendation within the revision of sure chapters. i'm additionally thankful to Springer­ Verlag, and especially to MR. WINSTANLEY and MR. EMERSON, for his or her contribu­ tion to the of completion of this quantity via translation and corrections. In con­ clusion i need to thank MRS. WALKER, MR. BISCHOFF, MRS. SEEKER, and MR. BERGSTEDT of Springer-Verlag for his or her valuable help.

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Kinderheilk. Vol. 5, p. 457-552. : Observation de Botanique. Hist. Acad. Roy. , Paris, Annee 1748 (1752) p. : Botanologia: The English herbals: or, history of plants, p. 399. : Herzglykoside als Hemmstoffe fUr den aktiven Kalium- und Natriumtransport durch die Erythrocytenmembran. Helv. Physiol. Pharmacol. : De digitali purpurea. : Untersuchungen iiber die pharmakologisch wirksamen Bestandtheile der Digitalis purpurea. Arch. Exp. Path. Pharmak. : Beitrage zur Kenntnis der Meerzwiebel. Wbl. Ges.

Ann. Charite Krh. 1,622-691 (1850). Also in: Gesamte Beitriige zur Pathologie und Physiologie. : Dissertation sur les effects de la digitale pourpree dans l'hydropisie. : Tritium labeled cardiac glycosides: Digoxin (12 Alpha-3H). Biochem. Pharmacol. : Digitalis. : Tritium-labeling by exposure of organic compounds to tritium gas. J. Am. Chern. Soc. : Uber die Formel der Digitalisglykoside. Nachr. Ges. Wiss. Gottingen Math. Naturw. Kl. : An account of the foxglove, and some of its medical uses: With practical remarks on dropsy, and other diseases.

G. VIII, Fig. 3), differing from the natural ones only in the position of attachment of the butenolide ring to the steroidal 17p position, are also active and even possess a more favorable therapeutic index than naturally occuring representatives. While the synthetic work is impressive here, pharmacological data are sparse. MENDEZ et ai. (1974) noticed in experiments with the same substance, that the difference be- 18 T. W. GiiNrERT and H. H. A. LINDE tween a minimal therapeutic and an arrhythmogenic dose as well as the difference between an arrhythmogenic and a lethal dose is here more favorable than in glycosides with a normal lactone configuration.

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