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Cyclophosphamide - A Medical Dictionary, Bibliography, and by Icon Health Publications

By Icon Health Publications

In March 2001, the nationwide Institutes of well-being issued the subsequent caution: "The variety of websites supplying health-related assets grows on a daily basis. Many websites supply worthy details, whereas others could have details that's unreliable or misleading." additionally, as a result of speedy bring up in Internet-based details, many hours should be wasted looking, choosing, and printing.This publication used to be created for doctors, scholars, and participants of most of the people who are looking to behavior clinical study utilizing the main complex instruments to be had and spending the smallest amount of time doing so.

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Continued funding should allow us to sustain the vigor of our activities and therefore meet our specific aims. Founded in 1898, RPCI was one of the first institutions dedicated exclusively to the research and treatment of cancer and allied diseases. The campus spans 25 acres in downtown Buffalo and consists of 15 research and clinical buildings with approximately one million square feet of space. Projected statistics for fiscal year 1996-1997 include 2381 new cancer cases, 5300 hospital admissions, and 104,000 outpatient visits from patients in 42 states and 22 foreign countries.

Our previous studies demonstrated that nicotine inhibits cytokine and chemotherapeutic druginduced apoptosis of a variety of tumor cell lines, including those types related to tobacco use. We hypothesize that the ability of nicotine to inhibit to inhibit apoptosis may promote tobacco-related carcinogenesis as well as decrease the efficacy of cancer therapies. The aims of this proposal are: 1) to further define the conditions under which nicotine inhibits apoptosis in tumor cell lines and in normal epithelial cells; 2) investigate the molecular mechanism in which nicotine obstructs the apoptotic pathway; 3) determine if nicotine will decrease the efficacy of chemotherapy in a mouse model.

Director of Cancer Center, Professor Of; Medicine; Columbia University Health Sciences Po Box 49 New York, Ny 10032 Timing: Fiscal Year 2002; Project Start 01-MAY-1995; Project End 31-DEC-2003 Summary: The Columbia University was accepted for probationary membership at the May 1994 SWOG meeting. The specific aims of our first modest (25,000 dollars) grant was to build the infrastructure for SWOG participation-- hire and train CRAs and research nurses, provide travel for physician investigators to become involved in SWOG, and recruit affiliated community cancer centers.

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