By Howard I Maibach (auth.), Dr. Bernard Gabard, Priv.-Doz. Dr. Christian Surber, Univ.-Professor Dr. med. Peter Elsner, Dr. Pierre Treffel (eds.)
Proof of the efficacy of dermatological items is a prerequisite for scientific trying out and registration. Now, efficacy claims for cosmetics has to be both substantiated. This ebook offers a concise, useful yet accomplished evaluate of experimental versions used to reveal, strengthen and choose dermatological and beauty formulations. The authors are famous experts of their box and use a standardized method of the initiatives facilitating the studying for the under pressure scientist, for the R+D managers basic view in addition to for the novices within the field.
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Extra resources for Dermatopharmacology of Topical Preparations: A Product Development-Oriented Approach
In: Hibbott HW (ed) Handbook of cosmetic science. An introduction to principles and applications. Pergamon, Oxford, pp 257-294 35. Sherman P (1971) Consistency profiling, and evaluation of pharmaceutical products. Rheol Acta 10:121-126 36. Griffiths WAD, Wilkinson JD (1992) Topical therapy. In: Champion RH, Burton JL, Ebling FJG (eds) Textbook of dermatology (Rook/Wilkinson/Ebling). Blackwell Scientific Publications, London, pp 3037-3084 37. Thoma K (1983) Dermatika. , Mtinchen 38. MUller KH (1979) Systematik der Externa.
Similarly, the co-solvents may (and usually do) diffuse into the membrane, since these chemicals also constitute perme ants in the passive kinetic process down the concentration gradient. The presence of the adulterating co-solvent in the membrane matrix alters the solvent environment of the latter and this may also adversely affect the partition coefficient of the drug across the interface. The presence of co-solvent molecules on both sides of the interface would, theoretically, have a neutralising effect on partitioning, tending to force the partition coefficient closer to unity since the solvent environments on either side of the interface are made more similar by the entry of the co-solvent species.
The principle of "wet" on "wet" and the use of occlusive ointments for dry or chronic dermatoses is commonplace. , high alcohol concentrations, in inappropriate dermatological conditions. As the skin condition improves or changes after initial therapy, treatment has to be adjusted accordingly. If the prescriber remains cognisant of the comprehensive information available on the topical vehicle's features and performance then individualised treatment is possible and patient compliance will be enhanced.